In this study, the most important strategies of Muslim cultural interactions with Christians from the perspective of the Holy Quran, and in a descriptive-analytical manner, the strategies and principles governing relations with Christians by relying on verses of the Holy Quran with an educational approach to correct Christian attitudes toward the ummah Islam has been explored. The Qur'anic strategies in the field of cultural interaction with Christians include many educational effects that can be addressed to remove historical ambiguities, strengthen human virtues and perfections, and not violate the rights of other human beings. It is very important to respect the rights of the followers of Christianity and to pay attention to appropriate strategies with good behavior and tolerance in dealing with them on the basis of God-centeredness. The importance and necessity of the issue becomes clear when we consider that in soft war, one of the main strategies of the enemy is cultural aggression and creating hatred and enmity between religions and changing the lifestyle of Muslims.