The contemporary world and its emerging challenges have paid attention to the holistic view of human beings. In such a way that the four dimensions of human health have always been the subject of discussion and exploration among thinkers. Due to the importance of spiritual health over other aspects of health, different schools have presented different definitions of spiritual health from different angles, and the analysis of their views shows that the definition of human was the introduction of the old school. The current research, with the tools of library-reference collection and descriptive-analytical method and the level of analysis of content analysis, seeks to answer the question, what is the description of man and the foundations of anthropology in spiritual health based on the teachings of the Qur'an? The findings of the research indicate that the existing human being has two natures that have three areas of knowledge, desire and ability, and based on these three areas, three systems are formed in him: insight, tendency and performance system. These three systems based on monotheistic vision and with faith factor can direct those three areas and bring spiritual health with a healthy heart.